Alloa will include two new signings for the first time when East Fife visit Recreation Park.
Former Ayr United defender Jonathan Tiffoney and on-loan Rangers youngster Callum Gallagher will both be involved.
Manager Paul Hartley also has Mitch Megginson available after agreeing a further loan deal with Aberdeen, although Nicky Low has returned to Pittodrie at the end of his loan spell.
The second-placed side are without Michael Doyle following groin surgery and Martin Grehan, who has a calf problem, while Kevin Cawley is a major doubt due to a virus.
Hartley said: "We have an excellent home record but I know it will be tested by an East Fife side that have improved greatly under Billy Brown.
"After missing out when our game with Arbroath was postponed last week we cannot wait for kick off."
East Fife welcome back Craig Johnstone after a two-game ban as they look for their first win in three away games and the three points that would help their play-off push.
The Fifers will be without David Muir who has a foot injury and Gareth Wardlaw who has been ill.
"I began my time at East Fife a few months ago with a game against Alloa and we lost it 1-0," manager Billy Brown said.
"They are a good footballing side and deservedly beat us but our league position and points tally have improved a lot since then.
"It will be good to pit our wits against Alloa and see how much closer we have got to them during my time here."