Billy Reid takes charge of Hamilton for the 300th time when Morton visit New Douglas Park.
On-loan Rangers goalkeeper Blair Currie will make his first senior start with regular number one David Hutton suspended after picking up a red card against Falkirk.
Reid is set to be without Lee Kilday (hamstring) with Ali Crawford struggling to regain full fitness following a knee injury.
Reid said: "Everyone at Hamilton is still disappointed with David's dismissal as we felt he played the ball before the Falkirk player got there but we are sure that Blair will do well.
"We played really poorly the last time Morton were here and we want to make up for that."
Michael Tidser is doubtful for Morton.
The Ton midfielder picked up a knock in Tuesday night's crucial 1-0 win over Partick Thistle.
Stuart McCaffrey and David O'Brien both remain out injured as Pride of the Clyde manager Allan Moore looks for the victory that would take his side above their hosts in the Scottish First Division.
Moore said: "Beating Thistle took some of the pressure off and we now know that winning this game will lift us above Hamilton and even closer to safety.
"We have to raise our game all the same as we did not play as well as we can in midweek.
"It would be great if we put on the same type of display we did the last time we visited Hamilton and won 2-1."