Inverness CT manager Terry Butcher admitted ‘it wasn’t our day’ as his team lost 2-0 to Kilmarnock at Rugby Park.
Captain Richie Foran and attacker Andrew Shinnie were forced off with injuries in the first half of the match.
And things got even worse when a tackle by Charlie Taylor on William Gros saw the ball bounce straight to Killie’s Paul Heffernan to score the opening goal of the match.
The Irishman added a second goal to kill Inverness’ cup hopes and see them fall to a third straight defeat.
Butcher said: "We never get a chance like that, we have to create our chances. I just couldn't believe how it happened but it did and he has buried it and after that it's us trying to press the game and we got caught again.
"Your captain and most influential player gets taken off in the first half and it was always going to be difficult from there on," he added.
"I look at their bench and see (Manuel) Pascali, Heffernan and (Garry) Hay and people like that and our bench is made up of young kids.
"Our young kids came on and did well and got into the game but it was going to be hard."
Owain Tudur Jones and Billy McKay also suffered knocks during the match.
"We will get it scanned and we will see but someone landed on his knee," Butcher said. "It must have been bad for Richie to come off.
"I don't think Andy's is that serious. His hamstring is tight but it has not snapped or torn.
"McKay got studs on his ankle and Jones was hit by (Rory) McKeown's chin, bizarrely.
"That's the way it goes. It wasn't our day."