Livingston are hoping to beat Ayr for the first time in five attempts this season.
They are however likely to be without the injured trio of Jason Talbot, Liam Fox and Iain Russell.
The Lions have also lost their last four games at home and manager John Hughes is looking to correct both sequences this time out.
He said: "We played some really good stuff at Raith Rovers in midweek when we won 3-0 and now I am looking for us to do that at home.
"Ayr are a really hard working side but I feel that it is our turn to beat them.
"But we will have to match their dogged approach first and foremost to succeed."
Ayr continue to be without suspended loan midfielder Adam Dodd as they look to record a third successive win at the West Lothian home of their hosts.
The Honest Men have an injury doubt over defender Martyn Campbell, who has picked up a knee injury, with manager Brian Reid looking for his men to arrest a recent slide in form with four defeats in a row.
Reid said, "We are still creating good chances but we are not converting them and hopefully that can change against Livingston.
"Our spirit is still good and we have a very good record up there but it will be a tough game. If we can tighten up just a wee bit more and take our chances we can win there again."