Morton are without goalkeepers Colin Stewart and Matt McGinley as Queen of the South visit Cappielow.
However, the hosts have been boosted by the fact that on-loan Celtic stopper Dominic Cervi is available after missing out in the Scottish Cup tie against Deveronvale last weekend as his parent club refused him permission to play.
Defender Marc Smyth returns after injury, but Stuart McCaffrey, Ross Forsyth and Fouad Bachirou remain out with knocks as the Greenock side hope to end a run of three home league defeats in a row.
Manager Allan Moore said: "We have got to get back into the habit of winning games at home again, although I recognise that this will not an easy game to get three points from as they gave us a bit of a battering when they won 4-1 down at their place."
Queen of the South will be without injured central defender Mark Campbell as they look to repeat their best result of the season.
The Doonhamers defeated the then league leaders 4-1 back in September, but manager Gus McPherson is wary of reading too much into that success.
He said: "A few things worked in our favour that day as the weather was a bit freakish and we scored four goals in the first half with the elements at our backs. We then defended well when Morton tried to use them to their advantage.
"I would gladly settle for the same again but I know that Allan Moore will be sending out an attacking team who will want to make up for that score."