Partick entertain Falkirk without the suspended Paul Paton as they look to build on an important victory over Dundee.
The Jags have doubts over Aaron Sinclair, Chris Erskine and Kris Doolan, with Darren Cole already ruled out.
Firhill boss Jackie McNamara said: "I would like to give some of young players the chance to show what they can do in the first team over the last couple of games.
"But I have to get the balance right as I want us to finish as high in the table as we can.
"A win in this game would lift us above Falkirk and also give us our first success over them in the league so there is still plenty to play for."
Falkirk have ruled out Kieran Duffie.
The Bairns are also without Duffie's fellow full-back Thomas Scobbie, who remains absent due to an ankle problem.
Steven Pressley's side have to win and hope that Dundee slip up in order to regain second place in the table.
The club's technical director Alex Smith said: "We have had a good season with excellent cup runs and an unexpected challenge in the league but we do not want things to fizzle out.
"It is always a tough game with Partick and they will be coming into this one boosted by a great win at Dundee.
"We have to win to have any chance of finishing second and we will give it a real go at Firhill."