Edinburgh head coach Michael Bradley says it is about time his side tasted 1872 Cup victory over Scottish rivals Glasgow Warriors.
Glasgow are bidding to win the trophy for a fourth successive time and go into the game having won 23-14 at Scotstoun. Edinburgh are without Ross Ford for the game with Andy Titterell coming into the side.
Other changes see Fiji captain Netani Talei replace Stuart McInally, Dougie Fife in for Lee Jones and Sean Cox taking Izak van der Westhuizen’s place.
Heading into the game, Bradley said: "This a hugely important game for us, with PRO12 points, intercity rivalry and, of course, the 1872 Cup all wrapped up in the deciding derby clash between the two clubs.
"We need a good start, we need to get the tempo up and keep it there, move the ball, move our opponents, create space and punish any vacancies.
"The challenge will be to do that against one of the most shrewd and stingy defences in the division, and one which has added an extra level of attacking nous to their armoury, which we saw in full flow last weekend, in part thanks to a number of defensive lapses on our part.
"Derbies are special occasions and all of our supporters, players and management are very much on song in terms of believing that it's about time we won this cup. It will be another ferocious contest.”